王吉生口腔诊所 黑龙江 牡丹江 157421
摘要：目的：观察维生素C片研磨后局部涂抹治疗口腔溃疡的临床疗效及安全性。方法：选取2016年10月-2017年10月我院口腔溃疡患者40例，按随机数字表法分为对照组和实验组，各20例。对照组患者采用桂林西瓜霜局部治疗，每日2-3次；实验组患者采用维生素C片研磨成粉涂抹患处治疗，每日2-3次。观察两组患者临床疗效、溃疡症状消失时间、不良反应发生率、溃疡复发率和治疗满意度。结果：实验组患者临床总有效率显著高于对照组，差异有统计学意义（P＜0.05）。实验组患者溃疡症状消失时间为显著短于对照组；实验组患者溃疡复发率显著低于对照组；实验组患者治疗满意度显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：维生素C片研磨成粉末局部涂抹治疗口腔溃疡疗效显著，能明显缩短溃疡症状消失时间，降低复发率，提高治疗满意度，且安全性较好。
关键词：维生素C片研磨后局部涂抹；口腔溃疡；临床分析。
Clinical analysis of the treatment of oral ulcer after lapping of vitamin C tablets.
Abstract: objective: to observe the clinical efficacy and safety of vitamin C tablets in the treatment of oral ulcer after grinding. Methods: 40 patients with oral ulcer in our hospital from October 2016 to October 2017 were selected, and 20 cases were divided into control group and experimental group by random number table method. The patients in the control group were treated with local treatment of guilin watermelon cream, 2 to 3 times daily. In the experimental group, the patients were treated with vitamin C tablets, which were ground into powder and applied to the affected area two or three times a day. The clinical efficacy, the time of disappearance of ulcer symptoms, the incidence of adverse reactions, the recurrence rate of ulcer and the satisfaction of treatment were observed. Results: the total clinical efficiency of patients in the experimental group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). In the experimental group, patients with ulcer symptoms disappeared significantly shorter than the control group. The recurrence rate of ulcer in the experimental group was significantly lower than that in the control group. The treatment satisfaction was significantly higher in the experimental group than in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: vitamin C piece of ground into a powder apply oral ulcer with obvious therapeutic effect, can significantly reduce ulcer symptoms disappear time, reduce the recurrence rate and improve the treatment satisfaction, and better security.
Key words: vitamin C tablet after grinding, local smear; Oral ulcer; Clinical analysis.
口腔溃疡是口腔科门诊常见的疾病，发病年龄集中于14-59岁，且女性发病率稍高于男性。口腔溃疡对患者生活质量和情绪带来了一定的负面影响。口腔溃疡的治疗常采用抗菌药物、B族维生素和激素等，或局部使用西瓜霜，但其临床疗效和副作用存在一定争议。维生素C是一种抗氧化剂，可清除自由基，对神经细胞、血管内皮细胞等均具有保护作用。鉴于此，本研究观察了维生素C片局部涂抹治疗口腔溃疡的临床疗效及安全性。
1.资料与方法
1.1一般资料
选取2016年10月-2017年10月我院收治的口腔溃疡患者40例，按随机数字表法分为实验组和对照组，各20例。两组患者一般资料比较，差异均无统计学意义（P＞0.05），具有可比性。
1.2方法
对照组患者治疗方法：0.9%氯化钠注射液漱口，用无菌棉签擦干溃疡患处，于患处喷洒桂林西瓜霜，喷药范围以完全覆盖溃疡表面为准。直径为2-5mm的溃疡每日喷涂2次，直径为6-9mm的溃疡每日喷涂3次。实验组患者治疗方法：0.9%氯化钠注射液漱口，用无菌棉签擦干溃疡患处，将维生素C片研磨成粉末，均匀涂抹于患处，以完全覆盖溃疡表面为准。直径为2-5mm的溃疡 每日涂抹2次，直径为6-9mm的溃疡每日涂抹3次。两组患者均治疗3d后评价疗效。
2.结果
实验组患者临床总有效率为95.00%，显著高于对照组的80.00%，差异有统计学意义（P＜0.05），详见表1；实验组患者溃疡症状消失时间明显短于对照组，差异有统计学意义（P＜0.05）；两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。实验组患者复发率显著低于对照组，治疗满意度显著高于对照组，差异均有统计学意义（P＜ 0.05）。
表1 两组患者临床疗效比较（例）
3.讨论
目前，抗菌药物、B族维生素、激素、局部用药治疗是治疗口腔溃疡的临床 一线治疗方案。其中，局部对症处理是临床最常用的方法，其临床治疗的主要目标在于提高创面的愈合速度、缓解临床症状。综上所述，维生素C片研磨成粉末局部涂抹治疗口腔溃疡疗效显著，能明显缩短溃疡症状消失时间，降低复发率，提高治疗满意度，且安全性较好。
参考文献：
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论文作者:王吉生
论文发表刊物:《世界复合医学》2017年第12期
论文发表时间:2018/7/18
标签：实验组论文; 患者论文; 口腔溃疡论文; 溃疡论文; 维生素论文; 对照组论文; 局部论文; 《世界复合医学》2017年第12期论文;